Our key antibodies (Cat.# 3CV4, clones C518, C524, C527, C706, C715) bind to the N-terminal part of the nucleoprotein: N47-A173 (please see TechNotes for additional information on other clones). Several mutations found in circulating SARS-CoV-2 variants are located outside of this region, however, we aim to test all relevant and concerning mutations regardless of their location. Prevalence of nucleoprotein mutations changes over time, for up-to-date information see e.g. https://outbreak.info/compare-lineages.

We screen for the variants ourselves using recombinant antigens, however, we also have received feedback from our customers that have tested selected antibody pairs with live virus variant strains. We highly appreciate the feedback from our customers as it gives valuable information on the performance of some of the pairs with live virus samples.

Below we have compiled information regarding different variants and mutations. We continue to update this information regularly. To minimize the likelihood that a COVID-19 antigen test will fail to recognize emerging variants, we recommend using more than two antibodies in the assay (see page 3).